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Jules P P Meijerink Selected Research

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)

6/2022STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment.
12/2021MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance.
1/2021A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia.
1/2021T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies.
10/2020A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer.
1/2020T-cell lymphoblastic lymphoma and leukemia: different diseases from a common premalignant progenitor?
12/2019Multi-omic approaches to improve outcome for T-cell acute lymphoblastic leukemia patients.
1/2019The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL.
12/2016IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study.
7/2014PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events.
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Jules P P Meijerink Research Topics

Disease

25Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
06/2022 - 02/2003
21Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
06/2022 - 06/2006
7Leukemia
01/2019 - 10/2010
6Neoplasms (Cancer)
01/2022 - 05/2013
4Glucocorticoid Receptor Deficiency
05/2007 - 08/2005
3Neuroblastoma
10/2013 - 10/2011
2Lymphoma (Lymphomas)
01/2019 - 01/2012
2T-Cell Leukemia (Leukemia, T Cell)
01/2014 - 11/2010
1Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
01/2021
1Splenomegaly
01/2019
1Mitochondrial Diseases (Mitochondrial Disease)
01/2019
1Colorectal Neoplasms (Colorectal Cancer)
06/2017
1Aneuploidy (Aneuploid)
06/2017
1Primitive Neuroectodermal Tumors (PNET)
10/2013
1Chromosome Aberrations (Chromosome Abnormalities)
08/2013
1Infections
05/2013
1Ganglioneuroblastoma
03/2012
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/2011
1Hematologic Neoplasms (Hematological Malignancy)
10/2010
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
07/2006
1Colitis
07/2006

Drug/Important Bio-Agent (IBA)

6Messenger RNA (mRNA)IBA
10/2011 - 02/2003
4SteroidsIBA
06/2022 - 12/2016
4GlucocorticoidsIBA
06/2022 - 08/2005
4Transcription Factors (Transcription Factor)IBA
01/2021 - 07/2009
4Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2021 - 08/2005
4Proteins (Proteins, Gene)FDA Link
01/2019 - 04/2008
4Prednisolone (Predate)FDA LinkGeneric
10/2010 - 04/2005
4Asparaginase (Elspar)FDA Link
10/2010 - 04/2003
3Phosphotransferases (Kinase)IBA
01/2022 - 01/2016
3T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2014 - 04/2011
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2021 - 12/2016
2Biological ProductsIBA
10/2020 - 05/2007
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2016 - 07/2014
2TensinsIBA
01/2016 - 07/2014
2Small Interfering RNA (siRNA)IBA
05/2013 - 05/2008
2Anaplastic Lymphoma KinaseIBA
03/2012 - 10/2011
2Protein Isoforms (Isoforms)IBA
01/2012 - 09/2005
2EnzymesIBA
08/2011 - 02/2003
2Pharmaceutical PreparationsIBA
06/2006 - 04/2005
1Protein Kinase InhibitorsIBA
01/2022
1ruxolitinibIBA
12/2021
1AZD 6244IBA
12/2021
1Biomarkers (Surrogate Marker)IBA
12/2019
1Adenosine Triphosphate (ATP)IBA
01/2019
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019
1venetoclaxIBA
01/2019
1Complement Factor B (Factor B)IBA
01/2019
12- (4- morpholinoanilino)- 6- cyclohexylaminopurineIBA
06/2017
1NTRC 0066-0IBA
06/2017
1Interleukin-7 Receptors (Interleukin 7 Receptor)IBA
12/2016
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2016
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2016
1trichostatin A (A 300)IBA
10/2013
1Drug CombinationsIBA
10/2013
1theasinensin AIBA
10/2013
1DecitabineFDA Link
10/2013
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2013
19-arabinofuranosylguanineIBA
08/2011
1forodesineIBA
08/2011
1nelarabine (506U78)FDA Link
08/2011
1NucleosidesIBA
08/2011
1Homeodomain Proteins (Proteins, Homeobox)IBA
11/2010
1MicroRNAs (MicroRNA)IBA
10/2010
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
10/2010
1CytokinesIBA
06/2010
1Protein Tyrosine PhosphatasesIBA
06/2010
1multidrug resistance-associated protein 1IBA
12/2008
1Differentiation AntigensIBA
12/2008
1Neurofibromin 1 (Neurofibromin)IBA
04/2008
1ras ProteinsIBA
04/2008
1MucinsIBA
07/2006
1Dextran SulfateIBA
07/2006
1Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA
06/2006
1Vincristine (Oncovin)FDA LinkGeneric
04/2005
1Cytarabine (Cytosar-U)FDA LinkGeneric
02/2003

Therapy/Procedure

7Therapeutics
01/2021 - 09/2006
1Drug Therapy (Chemotherapy)
12/2019
1Heterologous Transplantation (Xenotransplantation)
07/2014
1Combination Drug Therapy (Combination Chemotherapy)
12/2008